Palladium‐Catalyzed C8‐Oxygenation of Naphthalene Derivatives: Direct Access to Naphtholactone Skeleton
نویسندگان
چکیده
Herein, a direct C8-oxygenation of naphthalene derivatives is described. Different carbonyl groups were used as directing group to deliver corresponding naphthols via palladium-catalyzed oxidation reaction using PhI(OAc)2 in TFA/TFAA mixture. Interestingly, when Weinreb amide was employed the group, naphtholactone skeleton directly obtained. This methodology applied synthesis variously substituted naphtholactones.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2021
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202100317